Usually if you're bombing one in from anywhere beyond mid-wicket, you want to throw it to the opposite side of the bowler. Like....towards the "catcher" (wicket-keeper). The reason for that is that the batsman that was hitting won't be running as fast out of the box as his batting partner, and also the wicket-keeper has on the equivalent of a catchers mitt whereas everyone else is bare handed. Little easier for him to catch a ball.

The sides switch every 6 balls (1 over), but for the most part you're just throwing it to the guy with the gloves on.

Think of it like there is only 2 "bases," and both are home plate. Each time the batsman runs to the other side is worth 1 run. Ground balls to the wall are 4, home runs are 6. But if you toss it to the guy with gloves on, he's in one of only two spots he can make an out (wicket). He's a pretty safe bet to yeet the ball at.